RESEARCH HIGHLIGHTS
Making use of molecular dynamics and Brownian dynamics to investigate various nanotubes as artificial ion channels. The main purpose of this
research is to reproduce the physiological attributes of gramicidin.
Visit our research page for more information.
Using the recently unveiled structure of the Potassium Channel we employ a combination of electrostatics, Brownian dynamics and molecular
dynamics to investigate the way in which this biological channel discriminates between potasisum and sodium ions, and reproduce some
physiological attributes of conduction.
Visit our potassium channel page for more
information.
THE BIOPHYSICS GROUP
The Biophysics Group (formerly the Protein Dynamics Unit) is interested in the permeation of ions through biological membrane channels such as potassium, calcium, sodium and gramicidin chanels. We use various theoretical and computational tools such as Molecular dynamics and Brownian dynamics to gain a physical insight into the permeation processes.
LATEST PUBLICATIONS
- Taira Vora, Ben Corry and Shin-Ho Chung.
Brownian dynamics study of flux ratios in sodium channels.
European Biophysical Journal. 38, 45-52, 2008.
PDF: full article - David Bisset and Shin-Ho Chung.
Efficacy of External Tetraethylammonium Block of the KcsA Potassium Channel: Molecular and Brownian Dynamics Studies.
Biochimica et Biophysica Act -- Biomembrane. 1778, 2273-2282, 2008.
PDF: full article - Dan Gordon, Vikram Krishnamurthy and Shin-Ho Chung.
A Generalised Langevin Algorithm for Studying Permeation Across Biological Ion Channels.
Molecular Physics 106 (No. 11), 1353-1361, 2008.
PDF: full article
