Collaborations 

Animations 

See our Animations and Demonstrations page

Current Research 

The Potassium Channel:

Using the recently unveiled structure of the Potassium Channel we employ a combination of electrostatics, Brownian dynamics and molecular dynamics to investigate the way in which this biological channel discriminates between potasisum and sodium ions, and reproduce some physiological attributes of conduction. 

Visit our potassium channel page for a chapter by chapter explanation of the this channel using samples from our recent narrated video of the K ⁺ channel.

The Calcium Channel: 

By making use of electrostatic calculations and Brownian dynamics simulations, we show how the mechanisms of permeation and selectivity in the calcium channel can arise from simple electrostatic properties. The calcium channel page details our latest results. 

Testing Continuum Models of Ion Channels:

 

We have been making a systematic study of the validity of continuum theories of biological ion channels by comparison with Brownian dynamics simulations. More details can be found here

Gramicidin A:

Here we show a summary of our efforts to determine the energy landscape in Gramicidin A using a variety of theoretical techniques. 

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